Public Class Form1
　Dim p As Point

　Private Sub PictureBox1_MouseDown(ByVal sender As Object, ByVal e As System.Windows.Forms.MouseEventArgs) Handles PictureBox1.MouseDown
　　p = e.Location
　End Sub

　Private Sub Form1_Load(ByVal sender As System.Object, ByVal e As System.EventArgs) Handles MyBase.Load
　　PictureBox1.Image = New Bitmap(PictureBox1.Size.Width, PictureBox1.Size.Height)
　End Sub

　'(最普通的笔)
　Private Sub PictureBox1_MouseMove(ByVal sender As Object, ByVal e As System.Windows.Forms.MouseEventArgs) Handles PictureBox1.MouseMove
　　If e.Button = Windows.Forms.MouseButtons.Left Then
　　　Dim newGraphics As Graphics = Graphics.FromImage(PictureBox1.Image)

　　　newGraphics.DrawLine(Pens.Black, p, e.Location)
　　　p = e.Location

　　　newGraphics.Dispose()

　　　PictureBox1.Refresh()
　　End If
　End Sub

　'(清除钮)
　Private Sub Button1_Click(ByVal sender As System.Object, ByVal e As System.EventArgs) Handles Button1.Click
　　Dim newGraphics As Graphics = Graphics.FromImage(Me.PictureBox1.Image)

　　newGraphics.Clear(Me.PictureBox1.BackColor)

　　newGraphics.Dispose()
　　PictureBox1.Refresh()
　End Sub

　'(存档钮)
　Private Sub Button2_Click(ByVal sender As System.Object, ByVal e As System.EventArgs) Handles Button2.Click
　　PictureBox1.Image.Save("C:\ABC.bmp")
　End Sub
End Class